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Promethazine is metabolized from the liver to several different compounds; the sulfoxides of promethazine and N-demethylpromethazine tend to be the predominant metabolites showing during the urine.If concomitant use of a CYP3A4 inhibitor is critical or if a CYP3A4 inducer is discontinued, consider dosage reduction of TYLENOL® with Codeine right up